反应详情

To (S)-3-methyl-2-{4′-[(benzoxazole-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-butyric acid tert-butyl ester was added 4 mL of TFA/CH2Cl2 (1:1). The solution was stirred at room temperature for 3 h. The solvents were removed under vacuum and the residue was triturated with ether. Filtration gave 90 mg of (S)-3-methyl-2-{4′-[(benzooxazole-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-butyric acid as a white solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.8 (dd, J=12.6, 6.8 Hz, 6 H) 1.9 (m, 1 H) 3.6 (dd, J=9.3, 6.1 Hz, 1 H) 7.6 (m, 1 H) 7.6 (m, 1 H) 7.8 (m, 6 H) 8.0 (m, 2 H) 8.1 (m, 3 H) 11.4 (s, 1 H).

1. customThe solvents were removed under vacuum
2. customthe residue was triturated with ether
3. filtrationFiltration