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Alternatively, 3-(4-fluoro-phenoxy)-phenylamine was prepared by a two-step procedure by heating a suspension of m-fluoronitrobenzene (4.06 g, 28.7 mmol), p-fluorophenol (3.21 g, 28.6 mmol) and K2CO3 (8.13 g, 58.8 mmol) in DMA (dimethylamine) (60 mL) at 150° C. for 3 hours. The brown reaction mixture was concentrated to one-quarter original volume, diluted with ethyl acetate (220 mL) and washed successively with water (220 mL), 1N NaOH (220 mL) and brine (220 mL). The organic layer was dried (MgSO4) and the solvent removed in vacuo to afford the diphenylether (5.30 g, 80%) as a brown oil.

1. customAlternatively, 3-(4-fluoro-phenoxy)-phenylamine was prepared by a two-step procedure
2. temperatureby heating
3. concentrationThe brown reaction mixture was concentrated to one-quarter original volume
4. additiondiluted with ethyl acetate (220 mL)
5. washwashed successively with water (220 mL), 1N NaOH (220 mL) and brine (220 mL)
6. dry with materialThe organic layer was dried (MgSO4)
7. customthe solvent removed in vacuo