反应详情

4-{1-[5-(4-Fluorophenyl)-2-methyl-tliiazol-4-yl]-methanoyl}-3-[4-(4-fluoro-pbenyl)-oxazol-2-ylmethyl]-piperazine-1-carboxylic acid tert-butyl ester (0.130 g) was dissolved in trifluoroacetic acid (10 ml) and stirred at rdom temperature for 2 hours. The reaction mixture was then evaporated to dryness at reduced pressure and the residue was chromatographed over silica gel. Elution with a gradient of 0 to 10% [9:1 methanol/conc. ammonia solution] in dichloromethane provided the title compound as a pale yellow gum (0.013 g), mass spectrum (API+) 481 [MH+], C25H22F2N4O2S requires 480.

1. customThe reaction mixture was then evaporated to dryness at reduced pressure
2. customthe residue was chromatographed over silica gel
3. washElution with a gradient of 0 to 10% [9:1 methanol/conc. ammonia solution] in dichloromethane