反应详情

Freshly prepared sodium ethoxide in ethanol (0.2M, 0.8 ml) was added to a solution of (4′-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]-N-cyclopropyl-5-fluoro-6-methyl-1,1′-biphenyl-3-carboxamide (Intermediate 34) (50 mg) in ethanol (1 ml) and the reaction stirred at room temperature for 18 hours. The reaction was reduced to dryness under vacuum and the residue partitioned between ethyl acetate and water. The organic phase dried (magnesium sulphate) and reduced to dryness under vacuum. The residue was purified by HPLC to give N-cyclopropyl-4′-[5-ethoxymethyl)-1,3,4-oxadiazol-2-yl]-5-fluoro-6-methyl-1,1′-biphenyl-3-carboxamide.

1. customthe residue partitioned between ethyl acetate and water
2. dry with materialThe organic phase dried (magnesium sulphate)
3. customThe residue was purified by HPLC