反应详情

A solution of ethyl 3-{(1E)-3-[2-(4-methylbenzoyl)-1H-pyrrol-1-yl]prop-1-enyl}benzoate (1.94 g) in 1N aqueous lithium hydroxide solution (10 ml), THF (10 ml) and methanol (10 ml) were stirred at 50° C. for 3 hours. Methanol and THF in the reaction solution were evaporated under reduced pressure, and the residue was diluted with water, and washed with diethyl ether. The aqueous layer was acidified with diluted hydrochloric acid solution, and extracted with ethyl acetate. The organic layer was washed with saturated saline, dried over magnesium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (1.66 g, yield for 2 steps: 93%).

1. customMethanol and THF in the reaction solution were evaporated under reduced pressure
2. additionthe residue was diluted with water
3. washwashed with diethyl ether
4. extractionextracted with ethyl acetate
5. washThe organic layer was washed with saturated saline
6. dry with materialdried over magnesium sulfate
7. customthe solvent was evaporated under reduced pressure