反应详情

Combine 1-(3,4,5-trimethoxybenzoyl)-3-(2-(4-(1-(4-fluorobenzyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-phenylpyrrolidine (0.45 g) and ethyl acetate (35 mL). Add dropwise a solution of methanesulfonic acid (0.24 g, 2.6 mmol) in ethyl acetate (2.5 mL). After 18 hours, add diethyl ether (100 mL) to form a solid. Repeatedly, decant solvent and add diethyl ether. Again, decant solvent, add diethyl ether, and evaporate in vacuo to give a solid. Dry the solid in vacuo at 82° C. to give the title compound: mp; 131-136° C.

1. customto form a solid
2. customRepeatedly, decant solvent
3. additionadd diethyl ether
4. customAgain, decant solvent
5. additionadd diethyl ether
6. customevaporate in vacuo
7. customto give a solid
8. customDry the solid in vacuo at 82° C.