反应详情

Combine 1-(3,4,5-trimethoxybenzoyl)-3-(2-(4-(1-(5-chlorothien-2-ylmethyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-(3,4-difluorophenyl) pyrrolidine (1.21 g, 1.61 mmol), and methanesulfonic acid (0.23 mL, 3.54 mmol), ethyl acetate (90 mL), and methanol (10 mL) and stir. After 18 hours, filter and evaporate the filtrate in vacuo to give a residue. Triturate the residue with diethyl ether to give a solid. Decant the solvent and add diethyl ether. Collect the solid by filtration and dry in vacuo at 82° C. to give the title compound. Elemental Analysis calculated for C39H42ClF2N5O4S.2 CH3SO3H.1.8 H2O: C, 50.52; H, 5.54; N, 7.18. Found: C, 50.67; H, 5.38; N, 7.22.

1. filtrationfilter
2. customevaporate the filtrate in vacuo
3. customto give a residue
4. customTriturate the residue with diethyl ether
5. customto give a solid
6. customDecant the solvent
7. additionadd diethyl ether
8. customCollect the solid
9. filtrationby filtration
10. customdry in vacuo at 82° C.