反应详情

6-Chloro-2-(4-methoxyanilino)-2,3,4,9-tetrahydro-1H-pyrrolo[3,4-b]quinoline-1,3,9-trione (2.72 g, 7.40 mM) was stirred in methanol (200 mL), and methanesulfonic acid (50 mL) was added. The tan suspension was heated to reflux for 16 hours during which it turned yellow. This yellow suspension was cooled to room temperature and filtered (the filtrate was saved for use in Example 8). The collected solids were washed with methanol to give the title compound as a yellow powder (1.19 g, 44%), mp 371-373° C.; MS(CI): 370 (M+H).

1. temperatureThe tan suspension was heated
2. temperatureto reflux for 16 hours during which it
3. filtrationfiltered (the filtrate
4. washThe collected solids were washed with methanol