Hydrochloric Acid → [6-(n-Hexylsulfonoyl)-2-[4-(n-hexylsulfonoyl)phenyl]benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]-phenyl] methanone, Hydrochloride

HRID 325155Notes

Reaction equation

HRID 325155 reaction equation
[CH2:1]([S:7]([C:10]1[CH:11]=[CH:12][C:13]2[C:17]([C:18]([C:20]3[CH:25]=[CH:24][C:23]([O:26][CH2:27][CH2:28][N:29]4[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]4)=[CH:22][CH:21]=3)=[O:19])=[C:16]([C:35]3[CH:40]=[CH:39][C:38]([S:41]([CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH3:49])(=[O:43])=[O:42])=[CH:37][CH:36]=3)[S:15][C:14]=2[CH:50]=1)(=[O:9])=[O:8])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[ClH:51]>C(OCC)(=O)C>[ClH:51].[CH2:1]([S:7]([C:10]1[CH:11]=[CH:12][C:13]2[C:17]([C:18]([C:20]3[CH:21]=[CH:22][C:23]([O:26][CH2:27][CH2:28][N:29]4[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]4)=[CH:24][CH:25]=3)=[O:19])=[C:16]([C:35]3[CH:40]=[CH:39][C:38]([S:41]([CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH3:49])(=[O:43])=[O:42])=[CH:37][CH:36]=3)[S:15][C:14]=2[CH:50]=1)(=[O:8])=[O:9])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18357255[6-(n-Hexylsulfonoyl)-2-[4-(n-hexylsulfonoyl)phenyl]benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]-phenyl] methanone

Product 1

HCID 131722013[6-(n-Hexylsulfonoyl)-2-[4-(n-hexylsulfonoyl)phenyl]benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]-phenyl] methanone, Hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

[6-(n-Hexylsulfonoyl)-2-[4-(n-hexylsulfonoyl)phenyl]benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]-phenyl] methanone (3 g) was dissolved in 20 ml of ethyl acetate and hydrochloric acid-saturated diethyl ether was added. No precipitate formed. The reaction mixture was evaporated to a thick oil and was triturated several times with diethyl ether and dried in vacuo at room temperature to afford 1.64 g of the title compound as a white amorphous and hygroscopic powder.

Workup

  1. customNo precipitate formed
  2. customThe reaction mixture was evaporated to a thick oil
  3. customwas triturated several times with diethyl ether
  4. customdried in vacuo at room temperature

Sources & evidence

ORD record
ord-ce98a606eb8543fdae1311e4f34ea62d
Source dataset
uspto-grants-2001_04
Patent number
US06221838B1

Reaction notes

Loading…