反应详情

4.47 g (9 mmol) of [6-hydroxy-2-(4-hydroxyphenyl)benzo-[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone was dissolved in 250 ml of tetrahydrofuran and 4 g (40 mmol) of n-butylisocyanate was added. The reaction mixture, at room temperature and under nitrogen, was allowed to react for 72 hours. The reaction mixture had evaporated by the end of this time and the residue was dissolved in a minimal amount of chloroform. This solution was chromatographed (HPLC) on a silica gel column, eluted with a linear gradient of chloroform to chloroform-methanol (19:1) to afford 4.87 g of the title compound as a tan amorphous powder.

1. customat room temperature
2. customto react for 72 hours
3. customThe reaction mixture had evaporated by the end of this time
4. dissolutionthe residue was dissolved in a minimal amount of chloroform
5. customThis solution was chromatographed (HPLC) on a silica gel column
6. washeluted with a linear gradient of chloroform to chloroform-methanol (19:1)