反应详情

According to the same procedure as in Preparation 46, a mixture of 5,7-dihydroxyspiro[2H-1-benzopyran-2,1'-cyclohexan]-4(3H)-one (prepared in Preparation 19) (0.248 g, 1.0 mmol), ethyl 4-bromobutyrate (0.215 g, 1.1 mmol), anhydrous potassium carbonate (0.207 g, 1.5 mmol), and acetonitrile (3 ml) is reacted and treated. The resulting extract is concentrated and the residue is purified by a silica gel column chromatography (eluent: acetone and dichlomethane, 1:50) to obtain the title compound as an oil (0.236 g, yield 64.9%).

1. customAccording to the same procedure as in Preparation 46
2. customis reacted
3. additiontreated
4. extractionThe resulting extract
5. concentrationis concentrated
6. customthe residue is purified by a silica gel column chromatography (eluent: acetone and dichlomethane, 1:50)