反应详情

A solution of 18.0 g (0.055 mol) of 2-bromo-1-(3,5-ditert.butyl-4-hydroxyphenyl)-ethanone and 7.6 g (0.05 mol) of 1-amino-2-mercaptoimidazole hydrochloride from step (a) in 150 ml of ethanol was refluxed for 9 hours. The residue remaining after evaporation of the solution was rendered alkaline by means of 50 ml of 2N sodium hydroxide solution and extracted with chloroform. In order to convert the product into the hydrochloride, an equimolar amount of ethereal hydrochloric acid was added to the dried chloroform phase, and the batch of crystals produced was filtered off under suction and crystallized from ethanol.

1. customafter evaporation of the solution
2. extractionextracted with chloroform
3. additionan equimolar amount of ethereal hydrochloric acid was added to the dried chloroform phase
4. customthe batch of crystals produced
5. filtrationwas filtered off under suction
6. customcrystallized from ethanol