HRID329841

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3776

Isopropanol

C3H8O

HCID7449

3-Nitrobenzaldehyde

C7H5NO3

HCID643756

未命名化合物

结构：CC(=O)CC(=O)OCCN1CCN(C(c2ccccc2)c2ccccc2)CC1

HCID11740518

2-[4-(Diphenylmethyl)piperazin-1-yl]ethyl 3-oxobutanoate

C23H28N2O3

PRODUCTS

生成物

结构：CCOC(=O)C1=C(C)NC(C)=C(C(=O)OCCN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1c1cccc([N+](=O)[O-])c1

HCID19871266

未命名化合物

收率 48.3%

PROCEDURE

实验过程

A mixture of m-nitrobenzaldehyde, 2-(4-benzhydryl-1-piperazinyl)ethyl acetoacetate and ethyl 3-aminocrotonate was reacted in isopropyl alcohol in the same manner as Example 1 to give 2-(4-benzhydryl-1-piperazinyl)ethyl ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate as a light yellow powder, m.p. 80°-82° C. (sintering). Yield 48.3%. IR(Nujol)cm-1 : 3320, 1695, 1680. NMR(CDCl3) δ: 1.18(3H,t,J=6,--CH2CH3), 2.33(6H,s, ##STR14## 4.08(2H,q,J=6, --CH2CH3), 4.15(2H,t,J=6, --COOCH2CH2 --), 4.18(1H,s,>N--CH<), 5.08(1H,s,C(4) --H), 5.79(1H,s,NH).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-95d69f90a2884464bdb1d6f0f2247631
来源数据集: uspto-grants-1990_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04892875
来源说明: uspto-grants-1990_01

反应 SMILES

[N+:1]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH:7]=O)([O-:3])=[O:2].[C:12]([O:18][CH2:19][CH2:20][N:21]1[CH2:26][CH2:25][N:24]([CH:27]([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH2:23][CH2:22]1)(=[O:17])[CH2:13]C(C)=O.[NH2:40]/[C:41](/[CH3:48])=[CH:42]\[C:43]([O:45][CH2:46][CH3:47])=[O:44].[CH:49](O)(C)[CH3:50]>>[CH3:49][C:50]1[NH:40][C:41]([CH3:48])=[C:42]([C:43]([O:45][CH2:46][CH3:47])=[O:44])[CH:7]([C:6]2[CH:9]=[CH:10][CH:11]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=2)[C:13]=1[C:12]([O:18][CH2:19][CH2:20][N:21]1[CH2:26][CH2:25][N:24]([CH:27]([C:34]2[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=2)[C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH2:23][CH2:22]1)=[O:17]