反应详情

To a mixture of 2-bromomethyl-6-fluoro-naphthalene (1.5 g, 5.9 mmoL) in CH3CN (30 mL) was added KCN (1.16 g, 17.8 mmoL). The reaction mixture was heated at reflux for 6 h before being concentrated. To the residue was added diethyl ether (100 mL) and H2O (15 mL). The organic layer was separated, dried and concentrated. The resultant residue was purified by silica gel column chromatography (ethyl acetate/hexane=1:10) to afford the (6-fluoro-naphthalen-2-yl)-acetonitrile (0.88 g, 70%).

1. temperatureThe reaction mixture was heated
2. temperatureat reflux for 6 h
3. concentrationbefore being concentrated
4. additionTo the residue was added diethyl ether (100 mL) and H2O (15 mL)
5. customThe organic layer was separated
6. customdried
7. concentrationconcentrated
8. customThe resultant residue was purified by silica gel column chromatography (ethyl acetate/hexane=1:10)