反应详情

The 7a-(5-phenyl-3-pyridinyl)-hexahydro-1H-pyrrolizine compound from step 25b was dissolved in ether (5 mL) and Et2O saturated with HCl (g) was added. The solvent was removed, and the solid was dried to afford the title compound as yellow needles (13.5 mg): mp 217°-220° C. (dec.); 1H NMR D2O, 300 MHz) δ2.17-2.47 (m, 4H), 2.57-2.73 (m, 4H), 3.41-3.50 (m, 2H), 3.87-3.97 (m, 2H), 7.60-7.68 (m, 3H), 7.75-7.81 (m, 2H), 8.60 (dd, J=2.0, 2.0 Hz, 1H), 8.87 (d, J=2.0 Hz, 1H), 9.04 (d, J=2.0 Hz, 1H); MS (CI/NH3) m/z: 265 (M+H)+. Anal. Calcd for C18H20N2.2.0 HCl.0.1 H2O: C, 63.76; H, 6.60; N, 8.26. Found: C, 63.62; H, 6.48; N, 8.02.

1. customThe solvent was removed
2. customthe solid was dried