反应详情

温度

55 °C

{4-[2-(2,4-Dichloro-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-2-oxo-2H-pyridin-1-yl}-acetic acid methyl ester (Example 121, 40 mg) was dissolved in MeOH (1 mL), and treated with 1N NaOH (0.183 mL). The reaction mixture was stirred at 55° C. (Bath temperature) for 2 h. The reaction mixture was then cooled down to r.t., pH adjusted to pH2 by addition of 1N aqueous HCl, and the MeOH evaporated in vacuo. The resulting suspension was then extracted twice with ethyl acetate, the combined organic phases washed with brine, dried over MgSO4 and concentrated in vacuo, leading to the title compound as off-white solid (33 mg). MS (m/e)=424.1 (MH+).

1. temperatureThe reaction mixture was then cooled down to r.t.
2. customthe MeOH evaporated in vacuo
3. extractionThe resulting suspension was then extracted twice with ethyl acetate
4. washthe combined organic phases washed with brine
5. dry with materialdried over MgSO4
6. concentrationconcentrated in vacuo