反应详情

(R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-4-tert-butoxy-4-oxobutanoic acid (8.2 g) in tetrahydrofuran (2 mL) was treated with BH3-THF (39.9 mL) overnight. The reaction mixture was quenched with water and extracted with dichloromethane. The combined organic layer was washed with brine, dried over MgSO4, filtered and concentrated. The residue was purified by flash chromatography, eluting with 30% ethyl acetate in petroleum ether, to provide the title compound.

1. customThe reaction mixture was quenched with water
2. extractionextracted with dichloromethane
3. washThe combined organic layer was washed with brine
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. concentrationconcentrated
7. customThe residue was purified by flash chromatography
8. washeluting with 30% ethyl acetate in petroleum ether