反应详情

温度

23 °C

To a solution of methyl N-(tert-butoxycarbonyl)-4-(2-fluorophenyl)-5-nitrilonorvalinate (3.88 g, 11.5 mmol) in ethanol (50 mL) was added Raney nickel (slurry in water, ca. 10 g). The mixture was placed under a balloon of hydrogen and the reaction was stirred at 23° C. for 4 hours. The mixture was filtered and concentrated to afford a mixture of 4 diastereomers. A solution of this residue in ethanol (100 mL) was stirred in the presence of solid potassium carbonate (1.30 g, 9.44 mmol) at 60° C. for 2 h. The bulk of the ethanol was removed under reduced pressure and the remaining slurry was diluted with water to afford a white precipitate. The precipitate was filtered, washed with water and then dried under vacuum at 40° C. for 18 hours. The enantiomers were separated using normal-phase HPLC using a ChiralPak® AD column, eluting with 40% hexane in ethanol (0.1% diethylamine used as a modifier) to afford the title compound as the second major enantiomer to elute. MS: m/z=331.1 (M+Na).

1. filtrationThe mixture was filtered
2. concentrationconcentrated
3. customto afford
4. additiona mixture of 4 diastereomers
5. customThe bulk of the ethanol was removed under reduced pressure
6. additionthe remaining slurry was diluted with water
7. customto afford a white precipitate
8. filtrationThe precipitate was filtered
9. washwashed with water
10. customdried under vacuum at 40° C. for 18 hours
11. customThe enantiomers were separated
12. washeluting with 40% hexane in ethanol (0.1% diethylamine