反应详情

To a solution of 8-bromo-2-chloro-4-nitro-10H-chromeno[3,2-b]pyridin-10-one (80 mg, 0.225 mmol) in 0.8 mL of DMF at 0° C. was added tetrabutylammonium fluoride (1M in THF, 0.45 mL, 0.450 mmol) dropwise. After 15 minutes, the reaction was quenched with saturated NH4Cl (20 mL) and extracted with ethyl acetate (2×10 mL). The combined organics were dried over sodium sulfate, filtered and evaporated to dryness. Purification of the crude residue by column chromatography (SiO2, CH2Cl2 to CH2Cl2/EA=100:3) gave 8-bromo-2-chloro-4-fluoro-10H-chromeno[3,2-b]pyridin-10-one as an off white solid.

1. customthe reaction was quenched with saturated NH4Cl (20 mL)
2. extractionextracted with ethyl acetate (2×10 mL)
3. dry with materialThe combined organics were dried over sodium sulfate
4. filtrationfiltered
5. customevaporated to dryness
6. customPurification of the crude residue by column chromatography (SiO2, CH2Cl2 to CH2Cl2/EA=100:3)