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HRID338656

反应详情

EQUATION

反应方程式

HRID 338656 的结构方程式

REACTANTS

反应物

2
结构：C1OC2CNC1C2.Cl
HCID21914364

2-Oxa-5-azabicyclo[2.2.1]heptane--hydrogen chloride (1/1)

C5H10ClNO

结构：C=C(C)[C@@H]1CC[C@]2(NCCN3C[C@@H]4CC3CS4(=O)=O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(C6=CC7C(C6)C7C(=O)OCC)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12
HCID89886506

未命名化合物

PRODUCTS

生成物

1
结构：C=C(C)[C@@H]1CC[C@]2(NCCN3C[C@@H]4CC3CO4)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(C6=CC7C(C6)C7C(=O)OCC)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12
HCID89886333

未命名化合物

PROCEDURE

实验过程

The title compound was prepared quantitative yield following the method described above for the preparation of ethyl 3-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-((2-((1S)-2,2-dioxido-2-thia-5-azabicyclo[2.2.1]heptan-5-yl)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl)bicyclo[3.1.0]hex-2-ene-6-carboxylate, using racemic (1S)-2-oxa-5-azabicyclo[2.2.1]heptane hydrochloride as the reactant. MS: m/e 685.6 (M+H)+, 2.83 min (method 6). 1H NMR (400 MHz, CHLOROFORM-d) δ 5.80 (br. s., 1H), 5.51-5.37 (m, 1H), 4.73 (d, J=2.0 Hz, 1H), 4.59 (dd, J=2.3, 1.5 Hz, 1H), 4.42 (s, 1H), 4.18-4.10 (m, 2H), 4.07 (d, J=7.8 Hz, 1H), 3.65 (dd, J=7.7, 1.6 Hz, 1H), 3.50 (s, 1H), 2.95 (dd, J=9.8, 1.5 Hz, 1H), 2.95-2.40 (m, 8H), 2.18 (dt, J=6.5, 3.3 Hz, 1H), 2.09-1.96 (m, 3H), 1.92-1.72 (m, 6H), 1.71 (s, 3H), 1.68-1.31 (m, 9H), 1.30-1.10 (m, 10H), 1.08-0.8 (m, 16).

WORKUP

后处理

  1. customm/e 685.6 (M+H)+, 2.83 min (method 6)