HRID338879

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID276

Carbamic acid, ion(1-)

CH2NO2-

HCID1548870

8-methoxyquinoline-2-carbaldehyde

C11H9NO2

结构：CC(C)(C)OC(=O)N(CCF)[C@H]1CCN([C@H](c2ccc(NN)nc2)C(F)(F)F)C1

HCID86707428

未命名化合物

PRODUCTS

生成物

结构：COc1cccc2ccc(-c3nnc4ccc([C@@H](N5CC[C@H](N(CCF)C(=O)OC(C)(C)C)C5)C(F)(F)F)cn34)nc12

HCID86707427

未命名化合物

PROCEDURE

实验过程

Prepared as described in Example 9B, Step F, using tert-butyl 2-fluoroethyl((S)-1-((R)-2,2,2-trifluoro-1-(6-hydrazinylpyridin-3-yl)ethyl)pyrrolidin-3-yl)carbamate (0.10 g, 0.237 mmol) in place of tert-butyl (S)-1-((R)-2,2,2-trifluoro-1-(6-hydrazinylpyridin-3-yl)ethyl)pyrrolidin-3-yl)carbamate and 8-methoxyquinoline-2-carbaldehyde (0.044 g, 0.237 mmol). LCMS APCI (+) m/z 589 (M+H).

WORKUP

后处理

customPrepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-45ebffca6c974673bb307edf4d828a7d
来源数据集: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08889704B2
来源说明: uspto-grants-2014_11

反应 SMILES

[F:1][CH2:2][CH2:3][N:4]([C@H:12]1[CH2:16][CH2:15][N:14]([C@H:17]([C:22]2[CH:23]=[N:24][C:25]([NH:28][NH2:29])=[CH:26][CH:27]=2)[C:18]([F:21])([F:20])[F:19])[CH2:13]1)[C:5](=[O:11])[O:6][C:7]([CH3:10])([CH3:9])[CH3:8].C(=O)([O-])N.[CH3:34][O:35][C:36]1[CH:37]=[CH:38][CH:39]=[C:40]2[C:45]=1[N:44]=[C:43]([CH:46]=O)[CH:42]=[CH:41]2>>[F:1][CH2:2][CH2:3][N:4]([C@H:12]1[CH2:16][CH2:15][N:14]([C@H:17]([C:22]2[CH:27]=[CH:26][C:25]3[N:24]([C:46]([C:43]4[CH:42]=[CH:41][C:40]5[C:45](=[C:36]([O:35][CH3:34])[CH:37]=[CH:38][CH:39]=5)[N:44]=4)=[N:29][N:28]=3)[CH:23]=2)[C:18]([F:21])([F:19])[F:20])[CH2:13]1)[C:5](=[O:11])[O:6][C:7]([CH3:10])([CH3:9])[CH3:8]