反应详情

tert-Butyl (S)-1-((R)-2,2,2-trifluoro-1-(3-(7-methoxy-6-methylquinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrrolidin-3-ylcarbamate (154 mg, 0.277 mmol) was stirred in TFA (3 mL) for 1 hour then concentrated. The residue was dissolved in minimum methanol and added dropwise to a 4N HCl in ether solution. The resulting solid was filtered and dried to yield (S)-1-((R)-2,2,2-trifluoro-1-(3-(7-methoxy-6-methylquinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrrolidin-3-amine (109 mg, 86.3% yield) hydrochloride as a solid. LCMS APCI (+) m/z 457 (M+H).

1. concentrationthen concentrated
2. dissolutionThe residue was dissolved in minimum methanol
3. additionadded dropwise to a 4N HCl in ether solution
4. filtrationThe resulting solid was filtered
5. customdried