反应详情

Ethyl 6-chloro-2-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}carbamoyl)-1H-indole-5-carboxylate (1.30 g, 2.63 mmol) (Synthesis Example 8, Stage 3) and potassium carbonate were initially charged in acetonitrile (39 ml) and admixed with iodomethane (561 mg, 3.95 mmol). The reaction mixture was heated under reflux overnight. After cooling to room temperature, the mixture was concentrated to dryness under reduced pressure, and the residue taken up in ethyl acetate and washed with water. The organic phase was dried over sodium sulphate, filtered and concentrated to dryness under reduced pressure.

1. temperatureThe reaction mixture was heated
2. temperatureunder reflux overnight
3. concentrationthe mixture was concentrated to dryness under reduced pressure
4. washwashed with water
5. dry with materialThe organic phase was dried over sodium sulphate
6. filtrationfiltered
7. concentrationconcentrated to dryness under reduced pressure