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HRID339262

反应详情

EQUATION

反应方程式

HRID 339262 的结构方程式

REACTANTS

反应物

3
结构：CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2cc([C@H]3C[C@@H](C(=O)N[C@@H]4CCCc5ccccc54)N(C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C3)ccc2C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C(C)(C)C
HCID72704974

未命名化合物

结构：CC(C)(C)OC(=O)N1CC(OS(=O)(=O)C(F)(F)F)=C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21
HCID86705901

未命名化合物

结构：COC(=O)[C@@H]1Cc2ccc(B3OC(C)(C)C(C)(C)O3)cc2CN1C(=O)OC(C)(C)C
HCID86705903

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)[C@@H]1Cc2ccc(C3=C[C@@H](C(=O)N[C@@H]4CCCc5ccccc54)N(C(=O)OC(C)(C)C)C3)cc2CN1C(=O)OC(C)(C)C
HCID86705902

未命名化合物

收率 83.1%

PROCEDURE

实验过程

Following a procedure analogous to that for the synthesis of Compound D of Example 22, (S)-tert-butyl 2-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)-4-(((trifluoromethyl)sulfonyl)oxy)-2,5-dihydro-1H-pyrrole-1-carboxylate (683 mg, 1.39 mmol) and (S)-2-tert-butyl 3-methyl 7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2,3(1H)-dicarboxylate (726 mg, 1.74 mmol) were converted to the title compound (730 mg, 83%). MS (ESI+) m/z 632.5 (M+H)+.