HRID339275

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C[C@@H](C(=O)N[C@H](C(=O)N1Cc2cc([C@H]3C[C@@H](C(=O)N[C@@H]4CCCc5ccccc54)N(C(=O)[C@@H](NC(=O)[C@H](C)N(C)C(=O)OC(C)(C)C)C(C)(C)C)C3)ccc2C[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)(C)C)N(C)C(=O)OC(C)(C)C

HCID86705906

未命名化合物

结构：Cc1nnc([C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)o1

HCID86705919

未命名化合物

PRODUCTS

生成物

HCID42047875

(αS)-5-Methyl-α-(phenylmethyl)-1,3,4-oxadiazole-2-methanamine

C11H13N3O

收率 52%

PROCEDURE

实验过程

Following a procedure analogous to that for the synthesis of Compound B of Example 78, (S)-tert-butyl (1-(5-methyl-1,3,4-oxadiazol-2-yl)-2-phenylethyl)carbamate (130 mg, 0.43 mmol) was converted to the title compound (45 mg, 52% over 2 steps) after preparative HPLC. 1H NMR (CDCl3) δ 7.38-7.14 (m, 1H), 4.43 (dd, J=8.4, 5.5 Hz, 1H), 3.27 (dd, J=13.6, 5.3 Hz, 1H), 3.04 (dd, J=13.6, 8.4 Hz, 1H), 2.53 (s, 3H); MS (ESI+) m/z 204.2 (M+H)+.