HRID339278

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)O

HCID77857

L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-

C14H19NO4

HCID239041

2-Propyn-1-amine

C3H5N

结构：C[C@@H](C(=O)N[C@H](C(=O)N1C[C@@H](c2ccc3c(c2)CN(C(=O)[C@@H](NC(=O)[C@H](C)N(C)C(=O)OC(C)(C)C)C(C)(C)C)[C@H](C(=O)N[C@@H]2CCCc4ccccc42)C3)C[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)(C)C)N(C)C(=O)OC(C)(C)C

HCID86705917

未命名化合物

PRODUCTS

生成物

结构：C#CCNC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C

HCID11673861

未命名化合物

收率 99%

PROCEDURE

实验过程

Following a procedure analogous to that for the synthesis of Compound D of Example 1, (S)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanoic acid (Aldrich, 355 mg, 1.34 mmol) and prop-2-yn-1-amine (Combi-Blocks, 86 μL, 1.34 mmol) were converted to the title compound (401 mg, 99%). 1H NMR (CDCl3) δ 7.39-7.16 (m, 5H), 6.01 (br s, 1H), 4.97 (br s, 1H), 4.33 (d, J=7.0 Hz, 1H), 4.07-3.84 (m, 2H), 3.08 (d, J=6.8 Hz, 2H), 2.20 (t, J=2.5 Hz, 1H), 1.47-1.33 (m, 9H); MS (ESI+) m/z 303.3 (M+H)+.