HRID339282

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)[C@@H]1C=C(c2ccc3c(c2)CN(C(=O)OC(C)(C)C)[C@H](C(=O)OC)C3)CN1C(=O)OC(C)(C)C

HCID86705924

未命名化合物

结构：CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2cc(N[C@H]3C[C@@H](C(=O)N[C@@H]4CCCc5ccccc54)N(C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C3)ccc2C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C(C)(C)C

HCID117710478

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@@H]1Cc2ccc([C@H]3C[C@@H](C(=O)OC)N(C(=O)OC(C)(C)C)C3)cc2CN1C(=O)OC(C)(C)C

HCID126517029

未命名化合物

收率 88.5%

PROCEDURE

实验过程

Following a procedure analogous to that for the synthesis of Compound C of Example 20, (S)-2-tert-butyl 3-methyl 7-((5)-1-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-2,5-dihydro-1H-pyrrol-3-yl)-3,4-dihydroisoquinoline-2,3(1H)-dicarboxylate (563 mg, 1.09 mmol) was converted to the title compound (500 mg, 88%). MS (ESI) m/z 519.5 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2aa2b92beac440aca82444b5dc11e4ad
来源数据集: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08889712B2
来源说明: uspto-grants-2014_11

反应 SMILES

CC(C)(C)[C@H](NC(=O)[C@@H](NC)C)C(N1[C@H](C(N[C@H]2C3C(=CC=CC=3)CCC2)=O)CC2C(=CC(N[C@H]3C[C@@H](C(=O)N[C@H]4C5C(=CC=CC=5)CCC4)N(C(=O)[C@@H](NC(=O)[C@@H](NC)C)C(C)(C)C)C3)=CC=2)C1)=O.[C:71]([O:75][C:76]([N:78]1[C@H:82]([C:83]([O:85][CH3:86])=[O:84])[CH:81]=[C:80]([C:87]2[CH:96]=[C:95]3[C:90]([CH2:91][C@@H:92]([C:104]([O:106][CH3:107])=[O:105])[N:93]([C:97]([O:99][C:100]([CH3:103])([CH3:102])[CH3:101])=[O:98])[CH2:94]3)=[CH:89][CH:88]=2)[CH2:79]1)=[O:77])([CH3:74])([CH3:73])[CH3:72]>>[C:71]([O:75][C:76]([N:78]1[C@H:82]([C:83]([O:85][CH3:86])=[O:84])[CH2:81][C@H:80]([C:87]2[CH:96]=[C:95]3[C:90]([CH2:91][C@@H:92]([C:104]([O:106][CH3:107])=[O:105])[N:93]([C:97]([O:99][C:100]([CH3:102])([CH3:101])[CH3:103])=[O:98])[CH2:94]3)=[CH:89][CH:88]=2)[CH2:79]1)=[O:77])([CH3:74])([CH3:72])[CH3:73]