反应详情

To (E)-tert-butyl(1-(2-((2-(4-iodopyridin-2-yl)hydrazono)methyl)quinolin-8-yl)piperidin-4-yl)methylcarbamate (178 mg, 0.304 mmol) was added iodobenzene diacetate (IBD) (127 mg, 0.395 mmol). The reaction was stirred for 2 hours. Additional IBD (0.5 eq) was added and the reaction was stirred for another 2 hours and then quenched with saturated Na2S2O3 (5 mL). The organic layer was extracted with DCM, dried (Na2SO4) and concentrated. The crude material was purified by silica gel chromatography (EtOAc/Hexane/MeOH 2:1:0.1) to provide the final product.

1. stirringthe reaction was stirred for another 2 hours
2. customquenched with saturated Na2S2O3 (5 mL)
3. extractionThe organic layer was extracted with DCM
4. dry with materialdried (Na2SO4)
5. concentrationconcentrated
6. customThe crude material was purified by silica gel chromatography (EtOAc/Hexane/MeOH 2:1:0.1)