HRID340045

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2763980

6-(Piperidin-1-yl)pyridine-3-carbaldehyde

C11H14N2O

结构：Oc1cc(CC(F)(F)F)c(-c2ccc3c(-c4nc5c([nH]4)CCNC5)n[nH]c3c2)cc1F

HCID178516038

未命名化合物

PRODUCTS

生成物

结构：Oc1cc(CC(F)(F)F)c(-c2ccc3c(-c4nc5c([nH]4)CCN(Cc4ccc(N6CCCCC6)nc4)C5)n[nH]c3c2)cc1F

HCID178516041

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 2-fluoro-4-[3-(4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-6-yl]-5-(2,2,2-trifluoro-ethyl)-phenol (100 mg, 0.21 mmol) and 3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-5′-carbaldehyde (88.2 mg, 0.46 mmol) using the method of Example 51. The crude material was purified initially over silica and finally by Prep TLC (Mobile Phase: 10% MeOH-DCM) to afford the title compound as an off white solid in 16.99% yield, 22 mg.

WORKUP

后处理

customThe crude material was purified initially over silica and finally by Prep TLC (Mobile Phase: 10% MeOH-DCM)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8827b689da6e45069d10b25775e946aa
来源数据集: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08895544B2
来源说明: uspto-grants-2014_11

反应 SMILES

[F:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:16]=[C:15]3[C:11]([C:12]([C:17]4[NH:18][C:19]5[CH2:24][CH2:23][NH:22][CH2:21][C:20]=5[N:25]=4)=[N:13][NH:14]3)=[CH:10][CH:9]=2)[C:5]([CH2:26][C:27]([F:30])([F:29])[F:28])=[CH:4][C:3]=1[OH:31].[N:32]1([C:38]2[CH:43]=[CH:42][C:41]([CH:44]=O)=[CH:40][N:39]=2)[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]1>>[F:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:16]=[C:15]3[C:11]([C:12]([C:17]4[NH:18][C:19]5[CH2:24][CH2:23][N:22]([CH2:44][C:41]6[CH:42]=[CH:43][C:38]([N:32]7[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]7)=[N:39][CH:40]=6)[CH2:21][C:20]=5[N:25]=4)=[N:13][NH:14]3)=[CH:10][CH:9]=2)[C:5]([CH2:26][C:27]([F:28])([F:29])[F:30])=[CH:4][C:3]=1[OH:31]