反应详情

温度

65 °C

To 30 ml of an acetonitrile solution of 3.9 g (16 mmol) of 4′-hydroxy-3′-methoxy-2-bromoacetophenone was added 3.2 g (34 mmol) of 2-aminopyrimidine, and the mixture was stirred at 65° C. for 2 hours. The precipitated crystals were suction filtered and dissolved in 100 ml of 50% methanol. This solution was mixed with 1.3 g of sodium hydrogencarbonate and stirred at room temperature for 10 minutes. The precipitated crystals were suction filtered, and recrystallized from 50 ml of 50% methanol, thereby giving 2.4 g of 2-(4-hydroxy-3-methoxyphenyl)imidazo[1,2-a]pyrimidine in an yield of 62%.

1. filtrationfiltered
2. dissolutiondissolved in 100 ml of 50% methanol
3. additionThis solution was mixed with 1.3 g of sodium hydrogencarbonate
4. stirringstirred at room temperature for 10 minutes
5. filtrationfiltered
6. customrecrystallized from 50 ml of 50% methanol