反应详情

温度

120 °C

To 7-(4-fluoro-phenyl)-imidazo[1,2-a]pyridine (0.1093 g, 0.52 mmol) and 3-amino-5-bromopyridine (0.181 g, 1.05 mmol) in DMF (2 mL) was added 0.5 M K2CO3 (2.06 mL, 1.03 mmol). The reaction vessel was purged with N2 and Pd(PPh3)4 (63 mg, 0.055 mmol) added. The vessel was further purged with N2 and then heated in the microwave at 120° C. for 30 mins. Further 3-amino-5-bromopyridine (0.13 g, 0.75 mmol) and Pd(PPh3)4 (43 mg, 0.037 mmol) were added and the reaction heated in the microwave at 140° C. for 1 hour. The solids were filtered and the filtrate was concentrated in vacuo. The residue was partitioned between H2O (20 ml) and EtOAc (2×20 mL). The combined organic phases were dried over MgSO4, filtered and concentrated in vacuo and the product used crude in the subsequent reaction.

1. additionadded
2. customThe vessel was further purged with N2
3. temperaturethe reaction heated in the microwave at 140° C. for 1 hour
4. filtrationThe solids were filtered
5. concentrationthe filtrate was concentrated in vacuo
6. customThe residue was partitioned between H2O (20 ml) and EtOAc (2×20 mL)
7. dry with materialThe combined organic phases were dried over MgSO4
8. filtrationfiltered
9. concentrationconcentrated in vacuo
10. customin the subsequent reaction