反应详情

To a solution of 3-(6-(4-methoxyphenyl)-9H-pyrido[2,3-b]indol-3-yl)benzenamine (23 mg, 0.06 mmol, 1 equiv.), in anhydrous pyridine (0.300 ml), benzenesulfonyl chloride (0.009 ml) is added under argon. The reaction is carried out at room temperature for 3 hours and is then quenched with H2O (5 ml). The aqueous layer is extracted with AcOEt (3×5 ml) and CH2Cl2 (5 ml). The organic layers are dried over MgSO4 and concentrated under reduced pressure. The crude product is purified over silica gel chromatography (eluant CH2Cl2/AcOEt 7:3) to afford the product as a white solid (15 mg, 0.03 mmol) in 50% yield.

1. customis then quenched with H2O (5 ml)
2. extractionThe aqueous layer is extracted with AcOEt (3×5 ml) and CH2Cl2 (5 ml)
3. dry with materialThe organic layers are dried over MgSO4
4. concentrationconcentrated under reduced pressure
5. customThe crude product is purified over silica gel chromatography (eluant CH2Cl2/AcOEt 7:3)