反应详情

温度

0 °C

A mixture of 3.12 g (10 mmol) of 2-(1-chloro-cyclopropyl)-1-(2-chlorophenyl)-3-(1,2,4-triazol-1-yl)-propan-2-ol and 45 ml of absolute tetrahydrofuran is treated at 20° C. with 8.4 ml (21 mmol) of n-butyl-lithium in hexane, and the mixture is stirred at 0° C. for 30 minutes. The reaction mixture is then cooled to -70° C., 0.32 g (10 mmol) of sulphur powder are added, and the mixture is stirred for 30 minutes at -70° C. It is heated to -10° C., and treated with ice-water and brought to a pH of 5 by adding dilute sulphuric acid. The mixture is extracted repeatedly using ethyl acetate, and the combined organic phases are dried over sodium sulphate and concentrated under reduced pressure. In this manner, 3.2 g (93% of theory) of 2-(1-chloro-cyclopropyl)-1-(2-chlorophenyl)-3-(5-mercapto-1 ,2,4-triazol-1-yl)-propan-2-ol are obtained in the form of a solid which, after recrystallization, melts at 138°-139° C.

1. temperatureThe reaction mixture is then cooled to -70° C.
2. stirringthe mixture is stirred for 30 minutes at -70° C
3. temperatureIt is heated to -10° C.
4. extractionThe mixture is extracted repeatedly using ethyl acetate
5. dry with materialthe combined organic phases are dried over sodium sulphate
6. concentrationconcentrated under reduced pressure