反应详情

To a solution of methyl 3-chloro-4-(3-(3-phenyl-7-propylbenzofuran-6-yloxy)propylthio)-phenylacetate (3.72 g, 7.31 mmol) prepared in last step and aqueous lithium hydroxide(1.0M; 14.62 ml; 14.62 mmol) in methanol (25 ml) was refluxed for 1 hr. The mixture was partitioned between isopropyl acetate and pH4 buffer. The organic was dried over sodium sulfate. The solvent was removed under reduced pressure, and the residue was purified by chromatography (silica gel, 50% methylene chloride in hexane) to afford the title compound. M.P: 143° C. ESI-MS: m/e-495(M+1)

1. temperaturewas refluxed for 1 hr
2. customThe mixture was partitioned between isopropyl acetate and pH4 buffer
3. dry with materialThe organic was dried over sodium sulfate
4. customThe solvent was removed under reduced pressure
5. customthe residue was purified by chromatography (silica gel, 50% methylene chloride in hexane)