反应详情

This compound was prepared in a manner analogous to that of Step I of Example 1, using 0.82 gram (0.0030 mole) of 4-(4-chloro-5-difluoromethoxy-1-methylpyrazol-3-yl)phenol, 0.95 gram (0.0036 mole) of methyl 2-(5-chloro-2-chloromethylphenoxy)propanoate (prepared in Steps A through D of this Example), and 0.62 gram (0.0045 mole) of potassium carbonate in N,N-dimethylformamide. The crude reaction product was subjected to column chromatography on silica gel, using 1:4 ethyl acetate and heptane as the eluant. The product-containing fractions were combined and concentrated under reduced pressure to an oil. The oil was triturated with heptane, yielding 0.68 gram of title compound, mp 61-64° C. The NMR spectrum was consistent with the proposed structure.

1. customThis compound was prepared in a manner analogous to that of Step I of Example 1
2. customThe crude reaction product
3. concentrationconcentrated under reduced pressure to an oil
4. customThe oil was triturated with heptane