反应详情

1H-NMR (CDCl3,ppm) δ: 1.34-1.81(19 H,m), 2.26-2.39(4 H,m), 2.51-2.59(2 H,m), 2.92-2.97(2 H,m), 3.16(3 H,s), 3.18-3.21(2 H,m), 4.69(1 H,br), 7.42-7.56(3 H,m), 7.93-7.96(2 H,m) (2) 4-Methoxy-1-(6-oxo-6-phenylhexyl)-4-tert-butoxycarbonylaminomethylpiperidine (3.35 g) and 15% hydrochloric acid-isopropyl alcohol (15 ml) were reacted and treated in the same manner as in Preparation Example 138(2) to give 2.25 g of 4-aminomethyl-4-methoxy-1-(6-oxo-6-phenylhexyl)piperidine dihydrochloride.