HCID 22499360, compound → HCID 68751392, compound
Reaction equation
[C:1]([O:5][C:6]([NH:8][CH:9]1[C:27](=[O:28])[N:26]2[CH:22]([CH2:23][CH:24]([O:29][C:30]3[C:39]4[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=4)[CH:33]=[CH:32][N:31]=3)[CH2:25]2)[C:21](=[O:40])[NH:20][C:19]2([C:41]([OH:43])=O)[CH:17]([CH2:18]2)[CH:16]=[CH:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:44]([C:47]1([S:50]([NH2:53])(=[O:52])=[O:51])[CH2:49][CH2:48]1)[CH2:45][CH3:46]>>[C:1]([O:5][C:6](=[O:7])[NH:8][CH:9]1[C:27](=[O:28])[N:26]2[CH:22]([CH2:23][CH:24]([O:29][C:30]3[C:39]4[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=4)[CH:33]=[CH:32][N:31]=3)[CH2:25]2)[C:21](=[O:40])[NH:20][C:19]2([C:41]([NH:53][S:50]([C:47]3([CH2:44][CH2:45][CH3:46])[CH2:49][CH2:48]3)(=[O:52])=[O:51])=[O:43])[CH:17]([CH2:18]2)[CH:16]=[CH:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1)([CH3:3])([CH3:2])[CH3:4]Participants
Procedure
Prepared from 14-tert-butoxycarbonylamino-18-(isoquinolin-1-yloxy)-2,15-dioxo-3,16-diaza-tricyclo[14.3.0.04,6]-nonadec-7-ene-4-carboxylic acid (50 mg, 0.075 mmol) and 1-propyl-cyclopropanesulfonic acid amide (16 mg, 0.098 mmol, prepared as described above) to give [18-(isoquinolin-1-yloxy)-2,15-dioxo-4-(1-propyl-cyclopropanesulfonylaminocarbonyl)-3,16-diaza-tricyclo[14.3.0.04,6]nonadec-7-en-14-yl]-carbamic acid tert-butyl ester as a white powder: 1H NMR (300 MHz, CD3Cl3) δ 0.82–0.93 (m, 5H), 1.23 (s, 9H), 1.30–1.94 (m, 17H), 2.28 (m, 1H), 2.54(m, 1H), 2.68 (dd, J=8.1 Hz, 3.2 Hz, 2H), 4.05 (m, 1H), 4.30 (m, 1H), 4.63–4.66 (m, 2H), 4.96–5.09 (m, 2H), 5.70 (m, 1H), 5.92 (s, 1H), 6.69 (s, 1H), 7.23 (m, 1H), 7.46 (t, J=8.1 Hz, 1H), 7.63 (t, J=8.1 Hz, 1H), 7.72 (d, J=8.1 Hz, 1H), 7.97(d, J=5.9 Hz, 1H), 8.17 (d, J=8.4 Hz, 1H), 10.12 (s, 1H). LC-MS (Method A, retention time: 3.77 min), MS m/z 738 (M++1).
Sources & evidence
- ORD record
- ord-0b58da2c00a84ee1b054dbcf19c47e55
- Source dataset
- uspto-grants-2007_02
- Patent number
- US07173004B2
Reaction notes
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