反应详情

The compound (63.1 mg) obtained in Example 39-2 was dissolved in methanol (2.0 ml) and then added with 2-imidazole carboxaldehyde (17.9 mg), followed by stirring at room temperature for 17 hours. After the solvent had been distilled off, the residue was dried under vacuum and then dissolved in methanol (2.5 ml). Subsequently, the solution was added with sodium borohydride (14.5 mg) and stirred at room temperature for 1 hour. The reaction solution was added with a saturated aqueous ammonium chloride solution (4.0 ml) and stirred at room temperature for 30 minutes. Then, the reaction solution was added with saturated saline solution and subjected to extraction with chloroform, followed by drying with anhydrous sodium sulfate. After the solvent had been distilled off, the residue obtained was purified through silica gel column chromatography (chloroform/acetone), thereby obtaining the subject compound (45.2 mg) as a yellow solid.

1. distillationAfter the solvent had been distilled off
2. customthe residue was dried under vacuum
3. dissolutiondissolved in methanol (2.5 ml)
4. additionSubsequently, the solution was added with sodium borohydride (14.5 mg)
5. stirringstirred at room temperature for 1 hour
6. additionThe reaction solution was added with a saturated aqueous ammonium chloride solution (4.0 ml)
7. stirringstirred at room temperature for 30 minutes
8. additionThen, the reaction solution was added with saturated saline solution
9. extractionsubjected to extraction with chloroform
10. dry with materialby drying with anhydrous sodium sulfate
11. distillationAfter the solvent had been distilled off
12. customthe residue obtained
13. customwas purified through silica gel column chromatography (chloroform/acetone)