反应详情

{2-[2-(4-Trifluoromethoxy-phenyl)-vinyl]-oxazol-4-yl}-methanol (0.050 g, 0.17 mmol) is dissolved in anhydrous tetrahydrofuran (THF) (2 ml) followed by addition of sodium tert-butoxide (NaOtBu) (0.019 g, 0.19 mmol). After stirring for 15 min at r.t. 3-chloro-6-(4-[1,2,3]triazol-1-yl-butyl)-pyridazine (0.035 g, 0.15 mmol) is added slowly and stirred for further 4 h at 60° C. Ethyl acetate (20 ml) is added, the mixture is washed with saturated ammonium chloride (NH4Cl), dried over Na2SO4 and concentrated in vacuo. After flash column chromatography (ethyl acetate/methanol 97:3) 3-(4-[1,2,3]triazol-1-yl-butyl)-6-{2-[2-(4-trifluoromethoxy-phenyl)-vinyl]-oxazol-4-ylmethoxy}-pyridazine is isolated as a colorless solid. Yield 0.049 g (69%).

1. stirringstirred for further 4 h at 60° C
2. washthe mixture is washed with saturated ammonium chloride (NH4Cl)
3. dry with materialdried over Na2SO4
4. concentrationconcentrated in vacuo