反应详情

Wash sodium hydride (2.71 g of a 60% solution in mineral oil, 67.66 mmol) three times with hexanes, then dilute with 85 mL of DMF. To this mixture add the HCl salt of 5-amino-1H-imidazole-4-carboxylic acid amide (5.0 g, 30.75 mmol) neat in four portions. The mixture generates gas and remains cloudy and turns a slightly green color. After mixing for 40 min., add 1-chloromethyl-3,5-bis-trifluoromethyl-benzene (8.88 g, 33.83 mmol). (The mixture again generates gas and darkens). Stir at RT for 2 days, then pour through a plug of Celite and wash with DMF (50 mL) and xylenes (50 mL). Remove the DMF via azeotropic distillation with xylenes under reduced pressure (5×50 mL), and then concentrate the residue under a steady stream of nitrogen for 18 h to provide the title compound as a dark purple solid. MS (ES) 351.1, 353.1 (M+1); 1H NMR (300 MHz, CDCl3) δ 7.70 (s, 1H), 7.58 (s, 2H), 7.31 (s, 2H), 6.96 (s, 1H), 5.46 (s, 2H), 5.10 (s, 2H).

1. washWash sodium hydride (2.71 g of a 60% solution in mineral oil, 67.66 mmol) three times with hexanes
2. additiondilute with 85 mL of DMF
3. additionAfter mixing for 40 min.
4. additionpour through a plug of Celite
5. washwash with DMF (50 mL) and xylenes (50 mL)
6. customRemove the DMF
7. distillationvia azeotropic distillation with xylenes under reduced pressure (5×50 mL)
8. concentrationconcentrate the residue under a steady stream of nitrogen for 18 h