Hydrochloric Acid → HCID 17961976, compound

HRID 349529Notes

Reaction equation

HRID 349529 reaction equation
[CH3:1][N:2]1[C:6]([NH:7]C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=[C:5]([CH2:27][CH2:28][NH:29]C(=O)OC)[CH:4]=[N:3]1.[ClH:34]>>[ClH:34].[ClH:34].[NH2:7][C:6]1[N:2]([CH3:1])[N:3]=[CH:4][C:5]=1[CH2:27][CH2:28][NH2:29]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 17962036HCID 17962036, compound

Product 1

HCID 17961976HCID 17961976, compound

Procedure

A mixture of methyl N-[2-(1-methyl-5-triphenylmethylaminopyrazol-4-yl)ethyl]carbamate (15.3 g, 34.7 mmol) and concentrated hydrochloric acid (80 ml) was stirred under reflux for 13 hours. The reaction mixture was washed with ethyl acetate. The organic layer was separated, and the aqueous layer was concentrated in vacuo. The residue was triturated with diisopropyl ether and dried in vacuo to give 2-(5-amino-1-methylpyrazol-4-yl)ethylamine dihydrochloride (6.1 g) as a colorless solid.

Workup

  1. temperatureunder reflux for 13 hours
  2. washThe reaction mixture was washed with ethyl acetate
  3. customThe organic layer was separated
  4. concentrationthe aqueous layer was concentrated in vacuo
  5. customThe residue was triturated with diisopropyl ether
  6. customdried in vacuo

Sources & evidence

ORD record
ord-9fb1e7b4f8414d4c9d11ccb33a4e0de1
Source dataset
uspto-grants-2007_02
Patent number
US07179801B2

Reaction notes

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