反应详情

A mixture of methyl N-[2-(1-methyl-5-triphenylmethylaminopyrazol-4-yl)ethyl]carbamate (15.3 g, 34.7 mmol) and concentrated hydrochloric acid (80 ml) was stirred under reflux for 13 hours. The reaction mixture was washed with ethyl acetate. The organic layer was separated, and the aqueous layer was concentrated in vacuo. The residue was triturated with diisopropyl ether and dried in vacuo to give 2-(5-amino-1-methylpyrazol-4-yl)ethylamine dihydrochloride (6.1 g) as a colorless solid.

1. temperatureunder reflux for 13 hours
2. washThe reaction mixture was washed with ethyl acetate
3. customThe organic layer was separated
4. concentrationthe aqueous layer was concentrated in vacuo
5. customThe residue was triturated with diisopropyl ether
6. customdried in vacuo