反应详情

To 5.0 g (19.6 mmol) 4-fluoro-N-(indan-2-yl)-benzamide was given, at 5–10° C., a nitrating mixture of 10 ml conc. nitric acid and 12 ml conc. sulfuric acid, followed by stirring over 3 h at room temperature. The mixture was worked up by pouring onto an ice/water mixture, extraction with ethyl acetate, washing of the organic phase with a solution of sodium hydrogen carbonate, drying and evaporating to dryness. The thus-obtained residue was crystallized form ethyl acetate/heptane. yield: 3.2 g (54%), mp.: 167° C.

1. customwas given, at 5–10° C.
2. washwashing of the organic phase with a solution of sodium hydrogen carbonate
3. customdrying
4. customevaporating to dryness
5. customThe thus-obtained residue was crystallized form ethyl acetate/heptane