Trimethyltin chloride → HCID 23070264, compound

Temperature

-78 °C

A solution of thieno[2,3-b]thiophene (2.81 g, 20 mmol) was dissolved in anhydrous THF (100 ml) and cooled to −78° C. under nitrogen. A solution of n-butyllithium (17.6 ml of a 2.5M solution in hexanes, 44 mmol) was added dropwise over 15 min, and the resulting solution was allowed to warm to RT and stirred at that temperature for 16 h. The resulting suspension was cooled to −78° C. and trimethyltin chloride (10.0 g, 50 mmol) was added at once as a solid. The reaction was allowed to warm to RT over 4 h and stirred at that temperature for an additional 20 h. The reaction was quenched by the addition of saturated sodium hydrogen carbonate (100 ml). Ethyl acetate (50 ml) was added and the layers separated. The organic layer was washed-with sodium carbonate (80 ml of a 2M aqeous solution) and brine (80 ml), dried (sodium sulfate), filtered and concentrated under reduced pressure. The resulting crude product was dry loaded onto a 20 g reverse phase silica column and eluted with acetonitrile. The first fraction was collected, concentrated and recrystallised from acetonitrile to afford the product as white flakes (4.15 g, 45%). M/Z cluster centred at 466 (M+). Found C, 31.1; H, 4.4; S,13.8, Calc. for C12H20S2Sn2 C, 30.9; H, 4.3; S, 13.8. 1H NMR (300 MHz, CDCl3) δ 7.23 (s, 2H), 0.38 (s,18H). 13C NMR (75 MHz, CDCl3) δ 152.4, 147.7, 142.7, 126.3, −8.2.

1. temperatureto warm to RT
2. temperatureThe resulting suspension was cooled to −78° C.
3. temperatureto warm to RT over 4 h
4. stirringstirred at that temperature for an additional 20 h
5. customThe reaction was quenched by the addition of saturated sodium hydrogen carbonate (100 ml)
6. additionEthyl acetate (50 ml) was added
7. customthe layers separated
8. dry with materialdried (sodium sulfate)
9. filtrationfiltered
10. concentrationconcentrated under reduced pressure
11. dry with materialThe resulting crude product was dry
12. washeluted with acetonitrile
13. customThe first fraction was collected
14. concentrationconcentrated
15. customrecrystallised from acetonitrile
16. customto afford the product as white flakes (4.15 g, 45%)

ORD record

ord-efffd494b2a94cde9c4394bfebcc9608

Source dataset

uspto-grants-2007_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07183418B2