反应详情

温度

60 °C

A mixture of N-{2-benzyloxy-5-(2-iodo-(1R)-1-[(triethylsilyl)oxy]-ethyl)-phenyl}-methanesulfonamide (EP 0 659 737) (4.48 g, 8 mmol) and sodium azide (0.65 g, 10 mmol) in 100 mL of hexamethylphosphoramide was stirred at 60° C. overnight. After cooling to room temperature the mixture was diluted with diethyl ether, washed with water, dried over Na2SO4 and concentrated under reduced pressure. The residue was dissolved in 200 mL of THF/H2O (10:1) and triphenylphosphine (2.62 g, 10 mmol) was added. After overnight stirring at room temperature, the solvents were removed and the residue was partitioned between ethyl acetate and water. The organic layers were combined and dried over MgSO4 and concentrated. The residue was redissolved in 100 mL of THF and tetrabutylammonium fluoride (10 mL, 1 M solution in THF) was added. The reaction was stirred for 2 hours then the solvent was removed in vacuo. The residue was purified by column chromatography on silica gel using triethylamine-methanol-methylene chloride (1:1:3) to give the title compound as a white solid; MS (ES) m/z: 337.4 (M++H).

1. temperatureAfter cooling to room temperature the mixture
2. washwashed with water
3. dry with materialdried over Na2SO4
4. concentrationconcentrated under reduced pressure
5. dissolutionThe residue was dissolved in 200 mL of THF/H2O (10:1)
6. stirringAfter overnight stirring at room temperature
7. customthe solvents were removed
8. customthe residue was partitioned between ethyl acetate and water
9. dry with materialdried over MgSO4
10. concentrationconcentrated
11. dissolutionThe residue was redissolved in 100 mL of THF
12. additiontetrabutylammonium fluoride (10 mL, 1 M solution in THF) was added
13. stirringThe reaction was stirred for 2 hours
14. customthe solvent was removed in vacuo
15. customThe residue was purified by column chromatography on silica gel