HRID351700

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID9877547

未命名化合物

结构：COc1ccc(NS(=O)(=O)c2ccc(N3CCC(=O)CC3)cc2)cc1OC

HCID12051790

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(NS(=O)(=O)c2ccc(N3CCC(NC[C@H](O)COc4ccc(O)cc4)CC3)cc2)cc1OC

HCID10120294

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 4-((2S)-3-Amino-2-hydroxy-propoxy)-phenol and Reference Example 73, N-(3,4-dimethoxy-phenyl)-4-(4-oxo-piperidin-1-yl)-benzenesulfonamide, according to the procedure of Example 1 as an off-white solid; mp 101-106° C.; 1H NMR (300 MHz, DMSO-d6) δ 1.15-1.30 (m, 2H), 1.70-1.90 (m, 2H), 2.50-2.90 (m, 5H), 3.61 (s, 3H), 3.63 (s, 3H), 3.60-3.90 (m, 5H), 6.45 (dd, 1H), 6.60-6.80 (m, 8H), 6.90 (d, 1H), 7.45 (d, 1H); MS (ES) m/z: 557.9 (MH+); HRMS Calcd. for C28H36N3O7S (MH+): 558.2274. Found: 558.2293.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1df5489cdd334bd1857be55efc1035e7
来源数据集: uspto-grants-2004_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06743787B2
来源说明: uspto-grants-2004_06

反应 SMILES

[NH2:1][CH2:2][C@H:3]([OH:13])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1.[CH3:14][O:15][C:16]1[CH:17]=[C:18]([NH:24][S:25]([C:28]2[CH:33]=[CH:32][C:31]([N:34]3[CH2:39][CH2:38][C:37](=O)[CH2:36][CH2:35]3)=[CH:30][CH:29]=2)(=[O:27])=[O:26])[CH:19]=[CH:20][C:21]=1[O:22][CH3:23]>>[CH3:14][O:15][C:16]1[CH:17]=[C:18]([NH:24][S:25]([C:28]2[CH:33]=[CH:32][C:31]([N:34]3[CH2:39][CH2:38][CH:37]([NH:1][CH2:2][C@H:3]([OH:13])[CH2:4][O:5][C:6]4[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=4)[CH2:36][CH2:35]3)=[CH:30][CH:29]=2)(=[O:27])=[O:26])[CH:19]=[CH:20][C:21]=1[O:22][CH3:23]