反应详情

1-[4-[4-[[2-[(E)-2-[4-(Trifluoromethyl)phenyl]ethenyl]-1,3-oxazol-4-yl]methoxy]phenyl]butyl]-1H-1,2,3-triazole(1.5 g) was dissolved in tetrahydrofuran (75 ml). Concentrated hydrochloric acid (0.3 ml) was added dropwise. The crystals were precipitated. The mixture was stirred at room temperature for 40 min and filtrated. The mixture was washed with ethyl acetate (3 ml) and dried under reduced pressure (40° C.) to give 1-[4-[4-[[2-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1,3-oxazol-4-yl]methoxy]phenyl]butyl]-1H-1,2,3-triazolehydrochloride (1.09 g, yield 67%).

1. customThe crystals were precipitated
2. filtrationfiltrated
3. washThe mixture was washed with ethyl acetate (3 ml)
4. customdried under reduced pressure (40° C.)