Hydrochloric Acid → HCID 22715039, compound

HRID 352086Notes

Reaction equation

HRID 352086 reaction equation
[F:1][C:2]([F:34])([F:33])[C:3]1[CH:8]=[CH:7][C:6](/[CH:9]=[CH:10]/[C:11]2[O:12][CH:13]=[C:14]([CH2:16][O:17][C:18]3[CH:23]=[CH:22][C:21]([CH2:24][CH2:25][CH2:26][CH2:27][N:28]4[CH:32]=[CH:31][N:30]=[N:29]4)=[CH:20][CH:19]=3)[N:15]=2)=[CH:5][CH:4]=1.[ClH:35]>O1CCCC1>[ClH:35].[F:34][C:2]([F:1])([F:33])[C:3]1[CH:4]=[CH:5][C:6](/[CH:9]=[CH:10]/[C:11]2[O:12][CH:13]=[C:14]([CH2:16][O:17][C:18]3[CH:23]=[CH:22][C:21]([CH2:24][CH2:25][CH2:26][CH2:27][N:28]4[CH:32]=[CH:31][N:30]=[N:29]4)=[CH:20][CH:19]=3)[N:15]=2)=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 6444692Mubritinib

Product 1

HCID 22715039HCID 22715039, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1-[4-[4-[[2-[(E)-2-[4-(Trifluoromethyl)phenyl]ethenyl]-1,3-oxazol-4-yl]methoxy]phenyl]butyl]-1H-1,2,3-triazole(1.5 g) was dissolved in tetrahydrofuran (75 ml). Concentrated hydrochloric acid (0.3 ml) was added dropwise. The crystals were precipitated. The mixture was stirred at room temperature for 40 min and filtrated. The mixture was washed with ethyl acetate (3 ml) and dried under reduced pressure (40° C.) to give 1-[4-[4-[[2-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1,3-oxazol-4-yl]methoxy]phenyl]butyl]-1H-1,2,3-triazolehydrochloride (1.09 g, yield 67%).

Workup

  1. customThe crystals were precipitated
  2. filtrationfiltrated
  3. washThe mixture was washed with ethyl acetate (3 ml)
  4. customdried under reduced pressure (40° C.)

Sources & evidence

ORD record
ord-508c076fecd64629bbe9d676a9382b61
Source dataset
uspto-grants-2004_06
Patent number
US06743924B2

Reaction notes

Loading…