Hydrochloric Acid → HCID 86742394, compound

HRID 35482Notes

Reaction equation

HRID 35482 reaction equation
CC1C(CS([C:11]2[NH:12][C:13]3[CH:19]=[C:18]([C:20]([F:23])([F:22])[F:21])[CH:17]=[CH:16][C:14]=3[N:15]=2)=O)=NC=CC=1.[NH2:24][CH2:25][CH2:26][SH:27].[ClH:28]>O1CCCC1>[Cl-:28].[NH2:24][CH2:25][CH2:26][S:27][S:27][CH2:26][C:25]1[C:19]([CH3:18])=[CH:13][CH:14]=[CH:16][N+:24]=1[C:11]1[NH:12][C:13]2[CH:19]=[C:18]([C:20]([F:21])([F:22])[F:23])[CH:17]=[CH:16][C:14]=2[N:15]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6058CysteamineHCID 212959192-[[(3-Methyl-2-pyridyl)methyl]sulphinyl]-5-(trifluoromethyl)benzimidazole

Product 1

HCID 86742394HCID 86742394, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

3.39 g of 2-[[(3-methyl-2-pyridyl)methyl]sulphinyl]-5-(trifluoromethyl)benzimidazole are dissolved in 50 ml of tetrahydrofuran and treated with 0.77 g of cysteamine. 40 ml of 3N hydrochloric acid are added at an internal temperature of 40°. After stirring at 40° for 10 minutes and at room temperature overnight the mixture is evaporated in vacuo. The residue is crystallized from tert.butyl methyl ether/ether. There is obtained 2-[[(2-aminoethyl)dithio]methyl]-3 -methyl-1-[5-(trifluoromethyl)-2-benzimidazolyl1pyridinium chloride of melting point 95°-100°.

Workup

  1. customis evaporated in vacuo
  2. customThe residue is crystallized from tert.butyl methyl ether/ether

Sources & evidence

ORD record
ord-b0d496cdc8f24d358b2f6b672a2dde63
Source dataset
uspto-grants-1988_08
Patent number
US04766133

Reaction notes

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