反应详情

A mixture of 0.35 g of 2-(4-formylphenoxymethyl)-3-methylimidazo[5,4-b]pyridine (prepared as described in Preparation 112), 0.31 g of 2,4-thiazolidinedione, 0.26 ml of piperidine and 10 ml of ethanol was heated under reflux for 4 hours. At the end of this time, the solvent was removed by distillation under reduced pressure and the residue was crystallized by trituration with water. The crystals were collected by filtration and washed with water and then with ethyl acetate, to give 0.38 g of the title compound, melting at 279°-281° C.

1. temperaturewas heated
2. temperatureunder reflux for 4 hours
3. customAt the end of this time, the solvent was removed by distillation under reduced pressure
4. customthe residue was crystallized by trituration with water
5. filtrationThe crystals were collected by filtration
6. washwashed with water