反应详情

5 g of 3-[(1-methyl-1H-tetrazol-5-yl)-thiomethyl]-7β-[(2R)-2-(4-BOC-aminophenyl)-2-(2-imidazolidone-1-carboxamido)-acetamido]-3-cephem-4-carboxylic acid diphenylmethyl ester are stirred at room temperature for 21/2 hours with 2.3 g of p-toluenesulphonic acid monohydrate in 50 ml of acetonitrile. After adding 500 ml of ether, filtering the precipitate with suction, washing with 300 ml of ether and drying in vacuo, 3-[(1-methyl-1H-tetrazol-5-yl)-thiomethyl]-7β-[(2R)-2-(4-aminophenyl)-2-(2-imidazolidone-1-carboxamido)-acetamido]-3-cephem-4-carboxylic acid diphenylmethyl ester p-toluenesulphonate is obtained [α]D20 =-37°±1° (0.758% in CH3OH).

1. filtrationfiltering the precipitate with suction
2. washwashing with 300 ml of ether
3. customdrying in vacuo