反应详情

Following the procedure of Example 1, 0.75 g. of 2-(2-dimethylaminomethyl-4-thiazolylmethylthio)ethylamine and 0.78 g. of 2-nitroamino-5-(6-methyl-3-pyridyl)methyl-4-pyrimidone were dissolved in 5 ml. of anhydrous ethanol and the resulting solution refluxed for about 1 day. The solvents were removed by evaporation and the residue extracted with ethyl acetate. The ethyl acetate extract was washed with water and dried. Evaporation of the ethyl acetate yielded crystals of 2-[2-(2-dimethylaminomethyl-4-thiazolylmethylthio)ethyl]amino-5-(6-methyl-3-pyridyl)methyl-4-pyrimidone which melted at about 154°-5° C. after recrystallization from an ethyl acetate-ether solvent mixture; yield=0.56 g.

1. customThe solvents were removed by evaporation
2. extractionthe residue extracted with ethyl acetate
3. extractionThe ethyl acetate extract
4. washwas washed with water
5. customdried
6. customEvaporation of the ethyl acetate yielded crystals of 2-[2-(2-dimethylaminomethyl-4-thiazolylmethylthio)ethyl]amino-5-(6-methyl-3-pyridyl)methyl-4-pyrimidone which melted at about 154°-5° C.
7. customafter recrystallization from an ethyl acetate-ether solvent mixture